Journal of Pathology and Translational Medicine

Bong Jae Lee

4 Articles

Glomus Tumor of the Sinonasal Tract: Two Case Reports and a Review of Literature.: Young Wha Koh, Bong Jae Lee, Kyung Ja Cho; Korean J Pathol. 2010;44(3):326-329.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.3.326

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Herein we describe two cases of nasal glomus tumor. Histological findings were typical, save for one which was quite large (3.1 cm in its greatest dimension) with an invasive growth pattern and increased ki-67 labeling index (up to 10%). These features raised a red flag of similarity to a recently described "invasive glomus tumor of nasal cavity", suggesting a more aggressive form of glomus tumor. However, objective criteria for this possibility is lacking at present and more similar case studies are needed to establish a truly aggressive form of glomus tumor.

Citations

Citations to this article as recorded by

Nasal Septum Glomus Tumor: A Rare Cause of Unilateral Nasal Obstruction
Adamantios Kilmpasanis, Zoi Apazidi-Kesoglou, Alexandros Poutoglidis, Sotiria Sotiroudi, Konstantinos Vlachtsis, Nikolaos Tsetsos
Ear, Nose & Throat Journal.2023; 102(6): 402. CrossRef
An Atypical Lesion in the Nasal Cavity: Glomus Tumor
Erbil Arık, Yasemin Gunduz, Gozde Cakirsoy Cakar, Halil Elden
Ear, Nose & Throat Journal.2023; : 014556132311588. CrossRef
A case of malignant glomus tumor (glomangiosarcoma) of the nasal cavity
Omar A Alhroub, Shimaa A Mahameed, Mohammad O Abdelhafez, Asil Alhroub, Hani Hour, Nabil Hasasna, Nazmi Kamal
Journal of Surgical Case Reports.2022;[Epub] CrossRef
Ethmoid glomangioma and oncogenic osteomalacia: a case report
Camila R. Muniz, Gabriela A. M. Bezerra, Viviane C. da Silva, Priscilla M. F. Aguiar, Gunter Gerson, Catarina B. D’Alva, André A. A. Nunes
Journal of Medical Case Reports.2021;[Epub] CrossRef
Large Glomus Tumor of The Lateral Nasal Wall : A Case Report
Bon Min Koo, Jong In Jeong, Dong Eun Kim
Journal of Clinical Otolaryngology Head and Neck Surgery.2019; 30(2): 243. CrossRef
Characteristics and prognosis of glomangiopericytomas: A systematic review
Eun Su Park, Jiyoung Kim, Sun-Young Jun
Head & Neck.2017; 39(9): 1897. CrossRef
Malignant Glomus Tumour (Glomangiosarcoma) with Additional Neuroendocrine Differentiation in a Horse
M. Peters, J. Grafen, C. Kuhnen, P. Wohlsein
Journal of Comparative Pathology.2016; 154(4): 309. CrossRef
A Case of Glomangioma of the Nasal Septum
Do Hun Kim
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2013; 56(9): 603. CrossRef

Metastatic Carcinomas to the Sinonasal Tract.: Eun Ju Kim, Bong Jae Lee, Kyung Ja Cho; Korean J Pathol. 2010;44(3):302-307.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.3.302

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Abstract PDF

BACKGROUND
Metastases to the sinonasal tract are rare but occur for many malignancies. The demographics of sinonasal metastases in Korea aren't well known.
METHODS
Nine cases of metastases to the sinonasal tract identified at Asan Medical Center from January, 1995 to December, 2007 were reviewed.
RESULTS
Metastatic carcinomas accounted for 2.4% of sinonasal malignancies and 4.7% of carcinomas. Six kinds of cancer metastasized to the sinonasal tract. They included hepatocellular carcinomas (nasal cavity and maxillary sinus), colonic adenocarcinomas (sphenoid sinus and maxillary sinus), clear cell renal cell carcinoma (nasal cavity), pulmonary small cell carcinoma (nasal cavity), follicular carcinoma of thyroid (sphenoid sinus), and breast ductal carcinoma (maxillary sinus). Primary sites had been known in 7 cases, but follicular carcinoma and one adenocarcinoma were diagnosed after sinus metastases. Histologically, they had ill-defined borders and involved both mucosae and bones. Microscopic findings were not different from those for the primary tumors.
CONCLUSIONS
The pattern of sinonasal metastases in Korea are different from western data regarding incidence, site, and type, with hepatocellular carcinoma and the nasal cavity being the most common type and site, respectively. Awareness of the possibility of metastases and their pattern is encouraged when examining sinonasal tumors.

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Metastatic Carcinomas to the Oral Cavity and Oropharynx
Su-Jin Shin, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho
Korean Journal of Pathology.2012; 46(3): 266. CrossRef

Juvenile Ossifying Fibroma: A Clinicopathologic Study of 8 Cases and Comparison with Craniofacial Fibro-osseous Lesions.: Sohyung Park, Bong Jae Lee, Jeong Hyun Lee, Kyung Ja Cho; Korean J Pathol. 2007;41(6):373-379.

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Abstract PDF: BACKGROUND
Juvenile ossifying fibroma (JOF) is defined as a variant of the ossifying fibroma, and the latter includes juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma (JPOF). JOF can be distinguished from other craniofacial fibroosseous lesions by its tendency to recur and its clinical mimicry of malignant bone tumors, but some clinical and histological features of JOF overlap with the other fibro-osseous lesions as well. We aimed to identify the clinicopathologic definition of JOF.
METHODS
Forty-two cases of fibro-osseous lesions were reviewed and they were classified into JOF, fibrous dysplasia (FD) and ossifying fibroma (OF).
RESULTS
JTOF had long, slender and anastomosing trabeculae of osteoid in a fibrocellular stroma, and JPOF had small ossicles resembling psammoma bodies with a thick collagenous rim in the fibrous stroma, which are features that differ from those of FD and OF. Radiologically, JOF and OF showed a well-defined lesion but FD exhibited an ill-defined lesion. Clinically, the average age of the JOF patients was the youngest, followed by OF and FD. For JOF, three cases had rapid growth and two others showed recurrences. JOF mainly occurred in the paranasal sinuses, OF in the mandible and FD in any craniofacial bone.
CONCLUSION
We demonstrated the distinct characteristics of JOF and these features may be helpful for the diagnosis and management of this malady.

Sinonasal Low-Grade Adenocarcinoma: Report of Three Cases with the Clinicopathologic and Immunohistochemical Findings.: Joon Seon Song, Shin Kwang Khang, Jooryung Huh, Bong Jae Lee, Kyung Ja Cho; Korean J Pathol. 2006;40(3):235-240.

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Abstract PDF: Low-grade adenocarcinomas that primarily arise within the sinonasal tract are uncommon tumors. We report here on three cases of primary sinonasal low-grade adenocarcinomas. The patients were 2 females and 1 male with ages of 48, 57 and 64, respectively. Microscopically, the tumors had a well developed tubulopapillary growth pattern that consisted of columnar or pseudostratified cells with eosinophilic cytoplasm, round to oval nuclei and rare mitotic activity. On immunohistochemistry, the tumor cells were strongly positive for cytokeratin 7, but they were negative for cytokeratin 20, CDX-2 and p53. The Ki-67 labeling index was very low (mean: 1.9%). Two patients developed recurrent tumors at the primary site after the initial surgery, but all the patients are presently alive without metastasis 6 years 8 months, 8 years 8 months, and 11 months after the initial diagnosis. When considering the progress of these tumors, we think that it's important to understand the pathology of this entity to avoid underdiagnosis because a complete excision is required for effective treatment.

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